Prevalence and Assessment of Stress among Patients with Chronic Illnesses, among the components that influenced the susceptibility to stress are genetic vulnerability, coping style, type of personality and social support. When we are encountered with a problem, we assess the seriousness of the problem and judge whether or not we have the resources necessary to cope with the problem. If we believe that the problem is serious and do not have the resources necessary to cope with the problem, we will perceive ourselves as being under stress. The Centre for Disease Control and Prevention of the United States estimates that stress account about 75% of all doctors’ visits. This includes the diverse span of physical complaints including, but not limited to headache, back pain, heart problems, upset stomach, stomach ulcer, sleep problems, tiredness and accidents, depression in patients with chronic diseases have lethal consequences in the longterm, overwhelm the coping strategies of patients and their caregivers, and may enhance the utilization of healthcare services. There are certain shreds of evidence that shows promising results regarding the rehabilitation of the respective disease, adopting a healthy lifestyle, and psychological and antidepressant drug therapy in reducing anxiety and depressive symptoms in patients.